Cooling agent WS12
N,2,3-Trimethyl-2-isopropylbutamide
CAS: 68489-09-8
Molecular Formula: C18H27NO2
Cooling agent WS12 - Names and Identifiers
Cooling agent WS12 - Physico-chemical Properties
| Molecular Formula | C18H27NO2 |
| Molar Mass | 289.41 |
| Density | 1.029±0.06 g/cm3(Predicted) |
| Boling Point | 447.8±28.0 °C(Predicted) |
| JECFA Number | 2079 |
| Solubility | DMSO: >20mg/mL |
| Vapor Presure | 0-0Pa at 20-50℃ |
| Appearance | White to off-white powder. |
| Color | white to off-white |
| pKa | 14.18±0.70(Predicted) |
| Storage Condition | -20°C |
Cooling agent WS12 - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 50 - Very Toxic to aquatic organisms |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
Cooling agent WS12 - Reference Information
| FEMA | 4681 | (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE |
| LogP | 3.95 at 22℃ and pH7.7 |
| use | WS-12 has mint-like cool taste, and can be used as a cool taste enhancer for oral care, chewing gum and children's sugar. It can also be used as a cooler for skin and lipstick. |
| biological activity | WS-12 is an agonist of TRPM8 with an EC50 value of 39 nM. |
| target | EC50: 39 nM (TRPM8) |
Last Update：2024-04-10 22:29:15
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Cooling agent WS12
(1S,3AR,6AS)- 2-((2S)-2-(((2S)-2-环己基-2-(吡嗪羰基)氨基)乙酰基)氨基)-3,3-二甲基-1-氧代丁基)-八氢环戊二烯并[C]吡咯-1-羧酸乙酯
4-亚苄基-2,6-二叔丁基环己-2,5-二烯-1-酮
(R)-1-[(S)-2-二-(4-甲氧基-3,5-二甲苯基膦基)二茂铁基]-乙基-二(2-甲苯基)膦
C.I. Reactive Blue
(1S,3aR,6aS)-2-((2S)-2-(((2S)-2-环己基-2-(吡嗪羰基)氨基)乙酰基)氨基)-3,3-二甲基-1-氧代丁基)-八氢环戊二烯并[c]吡咯-1-羧酸乙酯
ALPHA-GLUCAN PHOSPHORYLASE
(R)-(1-(甲氧基(甲基)氨基)-4-甲基-1-氧代戊烷-2-基)氨基甲酸叔丁酯
3-溴-5-氯-2-吡啶羧酸
R-3-氨基氮杂环庚烷
(1S,3AR,6AS)- 2-((2S)-2-(((2S)-2-环己基-2-(吡嗪羰基)氨基)乙酰基)氨基)-3,3-二甲基-1-氧代丁基)-八氢环戊二烯并[C]吡咯-1-羧酸乙酯
4-亚苄基-2,6-二叔丁基环己-2,5-二烯-1-酮
(R)-1-[(S)-2-二-(4-甲氧基-3,5-二甲苯基膦基)二茂铁基]-乙基-二(2-甲苯基)膦
C.I. Reactive Blue
(1S,3aR,6aS)-2-((2S)-2-(((2S)-2-环己基-2-(吡嗪羰基)氨基)乙酰基)氨基)-3,3-二甲基-1-氧代丁基)-八氢环戊二烯并[c]吡咯-1-羧酸乙酯
ALPHA-GLUCAN PHOSPHORYLASE
(R)-(1-(甲氧基(甲基)氨基)-4-甲基-1-氧代戊烷-2-基)氨基甲酸叔丁酯
3-溴-5-氯-2-吡啶羧酸
R-3-氨基氮杂环庚烷